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The downsides of GLP-1s can be summed up in one message: You dont know what youre getting
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The issue is, and the reason why weve probably been talking about it so much in the past five years is certain triggers can continuously activate those mast cells, and if your mast cells are constantly being activated, or what we know is the syndrome of Mast Cell Activation Syndrome, youre constantly releasing those mediators
During 1,036,587 person-years of follow-up, cholangiocarcinoma occurred among 92 patients with use of GLP-1-receptor agonists (incidence rate, 26 per 100,000 patient-years) and among 157 patients with use of sulfonylureas (incidence rate, 23 per 100,000 patient-years)
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